Rita Redberg, a cardiologist at the University of California, San Francisco who editor in chief of the journal JAMA Internal Medicine. Those people might also be less likely to follow healthy lifestyle recommendations and therefore be more likely to have a heart attack or stroke, Virani said, perhaps accounting for what looks like a better outcome among those who took the drug.ĭrawing conclusions from a subgroup can be misleading, said Dr.
RITA LEE BEATLES TRIAL
In the group who hadn’t had a heart attack or stroke, more people dropped out of the trial if they received a placebo than if they received bempedoic acid.
Salim Virani, a preventive cardiologist affiliated with the Texas Heart Institute who is vice provost for research at Aga Khan University in Pakistan and who wasn’t involved in the study, puts less stock in the details of the results because it relied on a subset of trial participants who might not be representative of the larger population. The half who took bempedoic acid were 39% less likely to die from a cardiac event over the next three and a half years than those who received a placebo, a result Nissen called “simply stunning.”ĭr. The study looked at a portion of those studied - 4,200 people who hadn’t yet had a major cardiac event, such as a heart attack or stroke.
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